Pharmacokinetic and Pharmacodynamic Comparison of Sildenafil‐Bosentan and Sildenafil‐Ambrisentan Combination Therapies for Pulmonary Hypertension

To elucidate whether the pharmacokinetics (PK) and pharmacodynamics (PD) of sildenafil are influenced differently when it is coadministered with bosentan (S+B) or with ambrisentan (S+A), we evaluated the PK and PD profiles of sildenafil before and after 4–5 weeks of S+A or S+B treatment in patients...

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Detalhes bibliográficos
Publicado no:Clin Transl Sci
Main Authors: Hakamata, A, Odagiri, K, Miyakawa, S, Irisawa, H, Takeuchi, K, Inui, N, Tanaka, S, Uchida, S, Watanabe, H
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5351320/
https://ncbi.nlm.nih.gov/pubmed/26756977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cts.12382
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