RNA ligation in neurons by RtcB inhibits axon regeneration

Activity of the RNA ligase RtcB has only two known functions: tRNA ligation after intron removal and XBP1 mRNA ligation during activation of the unfolded protein response. Here, we show that RtcB acts in neurons to inhibit axon regeneration after nerve injury. This function of RtcB is independent of...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Kosmaczewski, Sara Guckian, Han, Sung Min, Han, Bingjie, Irving Meyer, Benjamin, Baig, Huma S., Athar, Wardah, Lin-Moore, Alexander T., Koelle, Michael R., Hammarlund, Marc
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2015
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4500288/
https://ncbi.nlm.nih.gov/pubmed/26100902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1502948112
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