RNA ligation in neurons by RtcB inhibits axon regeneration

Activity of the RNA ligase RtcB has only two known functions: tRNA ligation after intron removal and XBP1 mRNA ligation during activation of the unfolded protein response. Here, we show that RtcB acts in neurons to inhibit axon regeneration after nerve injury. This function of RtcB is independent of...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Proc Natl Acad Sci U S A
Päätekijät: Kosmaczewski, Sara Guckian, Han, Sung Min, Han, Bingjie, Irving Meyer, Benjamin, Baig, Huma S., Athar, Wardah, Lin-Moore, Alexander T., Koelle, Michael R., Hammarlund, Marc
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2015
Aiheet:
Biological Sciences
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4500288/
https://ncbi.nlm.nih.gov/pubmed/26100902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1502948112
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