RNA ligation in neurons by RtcB inhibits axon regeneration

Activity of the RNA ligase RtcB has only two known functions: tRNA ligation after intron removal and XBP1 mRNA ligation during activation of the unfolded protein response. Here, we show that RtcB acts in neurons to inhibit axon regeneration after nerve injury. This function of RtcB is independent of...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Kosmaczewski, Sara Guckian, Han, Sung Min, Han, Bingjie, Irving Meyer, Benjamin, Baig, Huma S., Athar, Wardah, Lin-Moore, Alexander T., Koelle, Michael R., Hammarlund, Marc
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4500288/
https://ncbi.nlm.nih.gov/pubmed/26100902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1502948112
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