Genome-wide binding and mechanistic analyses of Smchd1-mediated epigenetic regulation

Structural maintenance of chromosomes flexible hinge domain containing 1 (Smchd1) is an epigenetic repressor with described roles in X inactivation and genomic imprinting, but Smchd1 is also critically involved in the pathogenesis of facioscapulohumeral dystrophy. The underlying molecular mechanism...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Proc Natl Acad Sci U S A
Prif Awduron: Chen, Kelan, Hu, Jiang, Moore, Darcy L., Liu, Ruijie, Kessans, Sarah A., Breslin, Kelsey, Lucet, Isabelle S., Keniry, Andrew, Leong, Huei San, Parish, Clare L., Hilton, Douglas J., Lemmers, Richard J. L. F., van der Maarel, Silvère M., Czabotar, Peter E., Dobson, Renwick C. J., Ritchie, Matthew E., Kay, Graham F., Murphy, James M., Blewitt, Marnie E.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2015
Pynciau:
PNAS Plus
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4500281/
https://ncbi.nlm.nih.gov/pubmed/26091879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1504232112
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