Genome-wide binding and mechanistic analyses of Smchd1-mediated epigenetic regulation

Structural maintenance of chromosomes flexible hinge domain containing 1 (Smchd1) is an epigenetic repressor with described roles in X inactivation and genomic imprinting, but Smchd1 is also critically involved in the pathogenesis of facioscapulohumeral dystrophy. The underlying molecular mechanism...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Chen, Kelan, Hu, Jiang, Moore, Darcy L., Liu, Ruijie, Kessans, Sarah A., Breslin, Kelsey, Lucet, Isabelle S., Keniry, Andrew, Leong, Huei San, Parish, Clare L., Hilton, Douglas J., Lemmers, Richard J. L. F., van der Maarel, Silvère M., Czabotar, Peter E., Dobson, Renwick C. J., Ritchie, Matthew E., Kay, Graham F., Murphy, James M., Blewitt, Marnie E.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2015
Témata:
PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4500281/
https://ncbi.nlm.nih.gov/pubmed/26091879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1504232112
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