Prion protein (PrP) with amino-proximal deletions restoring susceptibility of PrP knockout mice to scrapie.

The 'protein only' hypothesis postulates that the prion, the agent causing transmissible spongiform encephalopathies, is PrP(Sc), an isoform of the host protein PrP(C). Protease treatment of prion preparations cleaves off approximately 60 N-terminal residues of PrP(Sc) but does not abrogat...

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Détails bibliographiques
Auteurs principaux: Fischer, M, Rülicke, T, Raeber, A, Sailer, A, Moser, M, Oesch, B, Brandner, S, Aguzzi, A, Weissmann, C
Format: Artigo
Langue:Inglês
Publié: 1996
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC450028/
https://ncbi.nlm.nih.gov/pubmed/8635458
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