Leinamycin E1 acting as an anticancer prodrug activated by reactive oxygen species

Leinamycin (LNM) is a potent antitumor antibiotic produced by Streptomyces atroolivaceus S-140, featuring an unusual 1,3-dioxo-1,2-dithiolane moiety that is spiro-fused to a thiazole-containing 18-membered lactam ring. Upon reductive activation in the presence of cellular thiols, LNM exerts its anti...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Huang, Sheng-Xiong, Yun, Bong-Sik, Ma, Ming, Basu, Hirak S., Church, Dawn R., Ingenhorst, Gudrun, Huang, Yong, Yang, Dong, Lohman, Jeremy R., Tang, Gong-Li, Ju, Jianhua, Liu, Tao, Wilding, George, Shen, Ben
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2015
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4500275/
https://ncbi.nlm.nih.gov/pubmed/26056295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1506761112
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