Selective resistance to the PARP inhibitor olaparib in a mouse model for BRCA1-deficient metaplastic breast cancer

Metaplastic breast carcinoma (MBC) is a rare histological breast cancer subtype characterized by mesenchymal elements and poor clinical outcome. A large fraction of MBCs harbor defects in breast cancer 1 (BRCA1). As BRCA1 deficiency sensitizes tumors to DNA cross-linking agents and poly(ADP-ribose)...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Henneman, Linda, van Miltenburg, Martine H., Michalak, Ewa M., Braumuller, Tanya M., Jaspers, Janneke E., Drenth, Anne Paulien, de Korte-Grimmerink, Renske, Gogola, Ewa, Szuhai, Karoly, Schlicker, Andreas, Bin Ali, Rahmen, Pritchard, Colin, Huijbers, Ivo J., Berns, Anton, Rottenberg, Sven, Jonkers, Jos
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4500240/
https://ncbi.nlm.nih.gov/pubmed/26100884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1500223112
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