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Intermolecular epistasis shaped the function and evolution of an ancient transcription factor and its DNA binding sites

Complexes of specifically interacting molecules, such as transcription factor proteins (TFs) and the DNA response elements (REs) they recognize, control most biological processes, but little is known concerning the functional and evolutionary effects of epistatic interactions across molecular interf...

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Vydáno v:eLife
Hlavní autoři: Anderson, Dave W, McKeown, Alesia N, Thornton, Joseph W
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4500092/
https://ncbi.nlm.nih.gov/pubmed/26076233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.07864
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