Evolution of DNA specificity in a transcription factor family produced a new gene regulatory module

Complex gene regulatory networks require transcription factors (TFs) to bind distinct DNA sequences. To understand how novel TF specificity evolves, we combined phylogenetic, biochemical, and biophysical approaches to interrogate how DNA recognition diversified in the steroid hormone receptor (SR) f...

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Bibliographic Details
Published in:Cell
Main Authors: McKeown, Alesia N., Bridgham, Jamie T., Anderson, Dave W., Murphy, Michael N., Ortlund, Eric A., Thornton, Joseph W.
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4447315/
https://ncbi.nlm.nih.gov/pubmed/25259920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.09.003
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