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Evolution of DNA specificity in a transcription factor family produced a new gene regulatory module
Complex gene regulatory networks require transcription factors (TFs) to bind distinct DNA sequences. To understand how novel TF specificity evolves, we combined phylogenetic, biochemical, and biophysical approaches to interrogate how DNA recognition diversified in the steroid hormone receptor (SR) f...
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| Publicado no: | Cell |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4447315/ https://ncbi.nlm.nih.gov/pubmed/25259920 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.09.003 |
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