Cleavage of sterol regulatory element binding proteins (SREBPs) by CPP32 during apoptosis.

Cellular cholesterol homeostasis is controlled by sterol-regulated proteolysis of membrane-bound transcription factors called sterol-regulatory element binding proteins (SREBPs). CPP32, a cysteine protease, was shown previously to cleave SREBP-1 and SREBP-2 in vitro at an aspartic acid between the b...

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Dettagli Bibliografici
Autori principali: Wang, X, Zelenski, N G, Yang, J, Sakai, J, Brown, M S, Goldstein, J L
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1996
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC449996/
https://ncbi.nlm.nih.gov/pubmed/8605870
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