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Ergosterol Regulates Sterol Regulatory Element Binding Protein (SREBP) Cleavage in Fission Yeast

In fission yeast, the endoplasmic reticulum membrane-bound proteins Sre1 and Scp1, orthologs of mammalian sterol regulatory element binding protein (SREBP) and Scap, monitor sterol synthesis as an indirect measure of oxygen supply. When cellular oxygen levels are low, sterol synthesis is inhibited,...

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Autors principals: Porter, Joshua R., Burg, John S., Espenshade, Peter J., Iglesias, Pablo A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3003404/
https://ncbi.nlm.nih.gov/pubmed/20959444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.144337
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