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Ergosterol Regulates Sterol Regulatory Element Binding Protein (SREBP) Cleavage in Fission Yeast

In fission yeast, the endoplasmic reticulum membrane-bound proteins Sre1 and Scp1, orthologs of mammalian sterol regulatory element binding protein (SREBP) and Scap, monitor sterol synthesis as an indirect measure of oxygen supply. When cellular oxygen levels are low, sterol synthesis is inhibited,...

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Detalhes bibliográficos
Main Authors: Porter, Joshua R., Burg, John S., Espenshade, Peter J., Iglesias, Pablo A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3003404/
https://ncbi.nlm.nih.gov/pubmed/20959444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.144337
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