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The kinase ABL phosphorylates the microprocessor subunit DGCR8 to stimulate primary microRNA processing in response to DNA damage
The DNA damage response network stimulates microRNA (miRNA) biogenesis to coordinate repair, cell cycle checkpoints and apoptosis. The multistep process of miRNA biogenesis involves the cleavage of primary miRNAs by the microprocessor complex comprised of the RNase Drosha and the RNA-binding protein...
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| Publicado no: | Sci Signal |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4499470/ https://ncbi.nlm.nih.gov/pubmed/26126715 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aaa4468 |
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