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Total Synthesis of the Antimitotic Marine Macrolide (−)-Leiodermatolide**
Leiodermatolide is an antimitotic macrolide isolated from the marine sponge Leiodermatium sp. whose potentially novel tubulin-targeting mechanism of action makes it an exciting lead for anticancer drug discovery. In pursuit of a sustainable supply, we report a highly stereocontrolled total synthesis...
Shranjeno v:
| izdano v: | Angew Chem Int Ed Engl |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
WILEY-VCH Verlag
2014
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4499261/ https://ncbi.nlm.nih.gov/pubmed/24481746 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201310164 |
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