Leiodermatolide, a potent antimitotic macrolide from the marine sponge Leiodermatium sp

Leiodermatolide is a structurally unique macrolide, isolated from the deep-water marine sponge Leiodermatium sp., which exhibits potent antiproliferative activity against a range of human cancer cell lines (IC(50) <10 nM) and dramatic effects on spindle formation in mitotic cells. Its unprecedent...

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Detalhes bibliográficos
Main Authors: Paterson, Ian, Dalby, Stephen M., Roberts, Jill C., Naylor, Guy J., Guzmán, Esther A., Isbrucker, Richard, Pitts, Tara P., Linley, Pat, Divlianska, Daniela, Reed, John K., Wright, Amy E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3875319/
https://ncbi.nlm.nih.gov/pubmed/21374771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201007719
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