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Leiodermatolide, a potent antimitotic macrolide from the marine sponge Leiodermatium sp
Leiodermatolide is a structurally unique macrolide, isolated from the deep-water marine sponge Leiodermatium sp., which exhibits potent antiproliferative activity against a range of human cancer cell lines (IC(50) <10 nM) and dramatic effects on spindle formation in mitotic cells. Its unprecedent...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3875319/ https://ncbi.nlm.nih.gov/pubmed/21374771 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201007719 |
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