ATP-dependent G-quadruplex unfolding by Bloom helicase exhibits low processivity

Various helicases and single stranded DNA (ssDNA) binding proteins unfold G-quadruplex (GQ) structures. However, the underlying mechanisms of this activity have only recently come to focus. We report kinetic studies on Bloom (BLM) helicase and human telomeric GQ interactions using single-molecule Fö...

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Udgivet i:Nucleic Acids Res
Main Authors: Budhathoki, Jagat B., Stafford, Edward J., Yodh, Jaya G., Balci, Hamza
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2015
Fag:
Genome Integrity, Repair and Replication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4499149/
https://ncbi.nlm.nih.gov/pubmed/25990739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv531
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