Large scale analysis of the mutational landscape in HT-SELEX improves aptamer discovery

High-Throughput (HT) SELEX combines SELEX (Systematic Evolution of Ligands by EXponential Enrichment), a method for aptamer discovery, with massively parallel sequencing technologies. This emerging technology provides data for a global analysis of the selection process and for simultaneous discovery...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Hoinka, Jan, Berezhnoy, Alexey, Dao, Phuong, Sauna, Zuben E., Gilboa, Eli, Przytycka, Teresa M.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2015
Subjects:
Computational Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4499121/
https://ncbi.nlm.nih.gov/pubmed/25870409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv308
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