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A Bayesian Partitioning Model for Detection of Multilocus Effects in Case-Control Studies

BACKGROUND: Genome-wide association studies (GWASs) have identified hundreds of genetic variants associated with complex diseases, but these variants appear to explain very little of the disease heritability. The typical single locus association analysis in a GWAS fails to detect variants with small...

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Detalhes bibliográficos
Publicado no:Hum Hered
Main Authors: Ray, Debashree, Li, Xiang, Pan, Wei, Pankow, James S, Basu, Saonli
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4499013/
https://ncbi.nlm.nih.gov/pubmed/26044550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000369858
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