CFTR expression from a BAC carrying the complete human gene and associated regulatory elements

The use of genomic DNA rather than cDNA or mini-gene constructs in gene therapy might be advantageous as these contain intronic and long-range control elements vital for accurate expression. For gene therapy of cystic fibrosis though, no bacterial artificial chromosome (BAC), containing the whole CF...

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Bibliographic Details
Published in:J Cell Mol Med
Main Authors: Kotzamanis, George, Abdulrazzak, Hassan, Gifford-Garner, Jennifer, Haussecker, Pei Ling, Cheung, Wing, Grillot-Courvalin, Catherine, Harris, Ann, Kittas, Christos, Kotsinas, Athanasios, Gorgoulis, Vassilis G, Huxley, Clare
Format: Artigo
Language:Inglês
Published: John Wiley & Sons, Ltd 2009
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4498948/
https://ncbi.nlm.nih.gov/pubmed/18657227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1582-4934.2008.00433.x
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