Novel cystine ester mimics for the treatment of cystinuria-induced urolithiasis in a knockout mouse model

OBJECTIVE: To assess the effectiveness of L-cystine dimethyl ester (CDME), an inhibitor of cystine crystal growth, for the treatment of cystine urolithiasis in a Slc3a1 knockout mouse model of cystinuria. METHODS: CDME (200 μg per mouse) or water was delivered by gavage daily for four weeks. Higher...

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Detalhes bibliográficos
Publicado no:Urology
Main Authors: Sahota, Amrik, Parihar, Jaspreet S., Capaccione, Kathleen M., Yang, Min, Noll, Kelsey, Gordon, Derek, Reimer, David, Yang, Ill, Buckley, Brian T., Polunas, Marianne, Reuhl, Kenneth R., Lewis, Matthew R., Ward, Michael D., Goldfarb, David S., Tischfield, Jay A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4498569/
https://ncbi.nlm.nih.gov/pubmed/25443947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.urology.2014.07.043
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