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Design, synthesis, and evaluation of L-cystine diamides as L-cystine crystallization inhibitors for cystinuria
To overcome the chemical and metabolic stability issues of L-cystine dimethyl ester (CDME) and L-cystine methyl ester (CME), a series of L-cystine diamides with or without N(α)-methylation was designed, synthesized, and evaluated for their inhibitory activity of L-cystine crystallization. L-Cystine...
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| Publicado no: | Bioorg Med Chem Lett |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5893393/ https://ncbi.nlm.nih.gov/pubmed/29571572 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2018.03.024 |
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