Design, synthesis, and evaluation of L-cystine diamides as L-cystine crystallization inhibitors for cystinuria

To overcome the chemical and metabolic stability issues of L-cystine dimethyl ester (CDME) and L-cystine methyl ester (CME), a series of L-cystine diamides with or without N(α)-methylation was designed, synthesized, and evaluated for their inhibitory activity of L-cystine crystallization. L-Cystine...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Bioorg Med Chem Lett
Main Authors: Yang, Yanhui, Albanyan, Haifa, Lee, Sumi, Aloysius, Herve, Liang, Jian-Jie, Kholodovych, Vladyslav, Sahota, Amrik, Hu, Longqin
Format: Artigo
Jezik:Inglês
Izdano: 2018
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5893393/
https://ncbi.nlm.nih.gov/pubmed/29571572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2018.03.024
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