Kindlin-2 controls TGF-β signalling and Sox9 expression to regulate chondrogenesis

The signals that control skeletogenesis are incompletely understood. Here we show that deleting Kindlin-2 in Prx1-expressing mesenchymal progenitors in mice causes neonatal lethality, chondrodysplasia and loss of the skull vault. Kindlin-2 ablation reduces chondrocyte density by decreasing cell prol...

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Pubblicato in:Nat Commun
Autori principali: Wu, Chuanyue, Jiao, Hongli, Lai, Yumei, Zheng, Wei, Chen, Ka, Qu, Hong, Deng, Weimin, Song, Pingping, Zhu, Ke, Cao, Huiling, Galson, Deborah L., Fan, Jie, Im, Hee-Jeong, Liu, Yujie, Chen, Ju, Chen, Di, Xiao, Guozhi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Pub. Group 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4498276/
https://ncbi.nlm.nih.gov/pubmed/26151572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8531
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