ATF4 promotes bone angiogenesis by increasing VEGF expression and release in the bone environment

Activating transcription factor 4 (ATF4) is a critical transcription factor for bone remodeling; however, its role in bone angiogenesis has not been established. Here we show that ablation of the Atf4 gene expression in mice severely impaired skeletal vasculature and reduced microvascular density of...

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Detalhes bibliográficos
Publicado no:J Bone Miner Res
Main Authors: Zhu, Ke, Jiao, Hongli, Li, Shuai, Cao, Huiling, Galson, Deborah L., Zhao, Zhongfang, Zhao, Xi, Lai, Yumei, Fan, Jie, Im, Hee-Jeong, Chen, Di, Xiao, Guozhi
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4394202/
https://ncbi.nlm.nih.gov/pubmed/23649506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.1958
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