Human γ-Glutamyl Transpeptidase 1: STRUCTURES OF THE FREE ENZYME, INHIBITOR-BOUND TETRAHEDRAL TRANSITION STATES, AND GLUTAMATE-BOUND ENZYME REVEAL NOVEL MOVEMENT WITHIN THE ACTIVE SITE DURING CATALYSIS

γ-Glutamyl transpeptidase 1 (GGT1) is a cell surface, N-terminal nucleophile hydrolase that cleaves glutathione and other γ-glutamyl compounds. GGT1 expression is essential in cysteine homeostasis, and its induction has been implicated in the pathology of asthma, reperfusion injury, and cancer. In t...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Main Authors: Terzyan, Simon S., Burgett, Anthony W. G., Heroux, Annie, Smith, Clyde A., Mooers, Blaine H. M., Hanigan, Marie H.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Protein Structure and Folding
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4498091/
https://ncbi.nlm.nih.gov/pubmed/26013825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.659680
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