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HIV-1 Vpr Protein Enhances Proteasomal Degradation of MCM10 DNA Replication Factor through the Cul4-DDB1[VprBP] E3 Ubiquitin Ligase to Induce G(2)/M Cell Cycle Arrest
Human immunodeficiency virus type 1 Vpr is an accessory protein that induces G(2)/M cell cycle arrest. It is well documented that interaction of Vpr with the Cul4-DDB1[VprBP] E3 ubiquitin ligase is essential for the induction of G(2)/M arrest. In this study, we show that HIV-1 Vpr indirectly binds M...
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| Publicado en: | J Biol Chem |
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| Autores principales: | , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2015
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4498075/ https://ncbi.nlm.nih.gov/pubmed/26032416 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.641522 |
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