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Hyperglycemia Promotes Schwann Cell De-differentiation and De-myelination via Sorbitol Accumulation and Igf1 Protein Down-regulation
Diabetes mellitus (DM) is frequently accompanied by complications, such as peripheral nerve neuropathy. Schwann cells play a pivotal role in regulating peripheral nerve function and conduction velocity; however, changes in Schwann cell differentiation status in DM are not fully understood. Here, we...
Zapisane w:
Wydane w: | J Biol Chem |
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Główni autorzy: | , , , , , , , , , , , , , , , , |
Format: | Artigo |
Język: | Inglês |
Wydane: |
American Society for Biochemistry and Molecular Biology
2015
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Hasła przedmiotowe: | |
Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4498049/ https://ncbi.nlm.nih.gov/pubmed/25998127 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.631291 |
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