Hyperglycemia Promotes Schwann Cell De-differentiation and De-myelination via Sorbitol Accumulation and Igf1 Protein Down-regulation

Diabetes mellitus (DM) is frequently accompanied by complications, such as peripheral nerve neuropathy. Schwann cells play a pivotal role in regulating peripheral nerve function and conduction velocity; however, changes in Schwann cell differentiation status in DM are not fully understood. Here, we...

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Publicado en:J Biol Chem
Autores principales: Hao, Wu, Tashiro, Syoichi, Hasegawa, Tomoka, Sato, Yuiko, Kobayashi, Tami, Tando, Toshimi, Katsuyama, Eri, Fujie, Atsuhiro, Watanabe, Ryuichi, Morita, Mayu, Miyamoto, Kana, Morioka, Hideo, Nakamura, Masaya, Matsumoto, Morio, Amizuka, Norio, Toyama, Yoshiaki, Miyamoto, Takeshi
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2015
Materias:
Cell Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4498049/
https://ncbi.nlm.nih.gov/pubmed/25998127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.631291
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