Loading...

APOBEC enzymes: mutagenic fuel for cancer evolution and heterogeneity

Deep sequencing technologies are revealing the complexities of cancer evolution, casting light on mutational processes fuelling tumor adaptation, immune escape, and treatment resistance. Understanding mechanisms driving cancer diversity is a critical step toward developing strategies to attenuate tu...

Full description

Saved in:
Bibliographic Details
Published in:Cancer Discov
Main Authors: Swanton, Charles, McGranahan, Nicholas, Starrett, Gabriel J., Harris, Reuben S.
Format: Artigo
Language:Inglês
Published: 2015
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4497973/
https://ncbi.nlm.nih.gov/pubmed/26091828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-15-0344
Tags: Add Tag
No Tags, Be the first to tag this record!