Combined Inhibition of Cyclin-Dependent Kinases (Dinaciclib) and AKT (MK-2206) Blocks Pancreatic Tumor Growth and Metastases in Patient-Derived Xenograft Models

KRAS is activated by mutation in the vast majority of cases of pancreatic cancer; unfortunately, therapeutic attempts to inhibit KRAS directly have been unsuccessful. Our previous studies showed that inhibition of cyclin-dependent kinase 5 (CDK5), reduces pancreatic cancer growth and progression, th...

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Bibliographic Details
Published in:Mol Cancer Ther
Main Authors: Hu, Chaoxin, Dadon, Tikva, Chenna, Venugopal, Yabuuchi, Shinichi, Bannerji, Rajat, Booher, Robert, Strack, Peter, Azad, Nilofer, Nelkin, Barry D., Maitra, Anirban
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4497872/
https://ncbi.nlm.nih.gov/pubmed/25931518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-15-0028
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