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A Chromosomal Memory Triggered by Xist Regulates Histone Methylation in X Inactivation

We have elucidated the kinetics of histone methylation during X inactivation using an inducible Xist expression system in mouse embryonic stem (ES) cells. Previous reports showed that the ability of Xist to trigger silencing is restricted to an early window in ES cell differentiation. Here we show t...

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Autors principals: Kohlmaier, Alexander, Savarese, Fabio, Lachner, Monika, Martens, Joost, Jenuwein, Thomas, Wutz, Anton
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2004
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC449785/
https://ncbi.nlm.nih.gov/pubmed/15252442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.0020171
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