Notch promotes recurrence of dormant tumor cells following HER2/neu-targeted therapy

Breast cancer mortality is principally due to recurrent tumors that arise from a reservoir of residual tumor cells that survive therapy. Remarkably, breast cancers can recur after extended periods of clinical remission, implying that at least some residual tumor cells pass through a dormant phase pr...

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Bibliographic Details
Published in:J Clin Invest
Main Authors: Abravanel, Daniel L., Belka, George K., Pan, Tien-chi, Pant, Dhruv K., Collins, Meredith A., Sterner, Christopher J., Chodosh, Lewis A.
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2015
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4497740/
https://ncbi.nlm.nih.gov/pubmed/25961456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI74883
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