Inhibition of Aerobic Glycolysis Represses Akt/mTOR/HIF-1α Axis and Restores Tamoxifen Sensitivity in Antiestrogen-Resistant Breast Cancer Cells

Tamoxifen resistance is often observed in the majority of estrogen receptor–positive breast cancers and it remains as a serious clinical problem in breast cancer management. Increased aerobic glycolysis has been proposed as one of the mechanisms for acquired resistance to chemotherapeutic agents in...

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Gepubliceerd in:PLoS One
Hoofdauteurs: Woo, Yu Mi, Shin, Yubin, Lee, Eun Ji, Lee, Sunyoung, Jeong, Seung Hun, Kong, Hyun Kyung, Park, Eun Young, Kim, Hyoung Kyu, Han, Jin, Chang, Minsun, Park, Jong-Hoon
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2015
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4497721/
https://ncbi.nlm.nih.gov/pubmed/26158266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0132285
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