The HIV protease inhibitor ritonavir blocks osteoclastogenesis and function by impairing RANKL-induced signaling

Highly active antiretroviral therapy (HAART), which includes HIV protease inhibitors (PIs), has been associated with bone demineralization. To determine if this complication reflects accelerated resorptive activity, we studied the impact of two common HIV PIs, ritonavir and indinavir, on osteoclast...

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Bibliografiske detaljer
Main Authors: Wang, Michael W.-H., Wei, Shi, Faccio, Roberta, Takeshita, Sunao, Tebas, Pablo, Powderly, William G., Teitelbaum, Steven L., Ross, F. Patrick
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2004
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC449740/
https://ncbi.nlm.nih.gov/pubmed/15254587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200415797
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