Interleukin-21 sustains inflammatory signals that contribute to sporadic colon tumorigenesis

Interleukin (IL)-21 triggers inflammatory signals that contribute to the growth of neoplastic cells in mouse models of colitis-associated colorectal cancer (CRC). Because most CRCs are sporadic and arise in the absence of overt inflammation we have investigated the role of IL-21 in these tumors in m...

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Bibliographic Details
Published in:Oncotarget
Main Authors: De Simone, Veronica, Ronchetti, Giulia, Franzè, Eleonora, Colantoni, Alfredo, Ortenzi, Angela, Fantini, Massimo C., Rizzo, Angelamaria, Sica, Giuseppe S., Sileri, Pierpaolo, Rossi, Piero, MacDonald, Thomas T., Pallone, Francesco, Monteleone, Giovanni, Stolfi, Carmine
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2015
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4496406/
https://ncbi.nlm.nih.gov/pubmed/25839161
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