ROS1 rearrangements in lung adenocarcinoma: prognostic impact, therapeutic options and genetic variability

BACKGROUND: While recent data show that crizotinib is highly effective in patients with ROS1 rearrangement, few data is available about the prognostic impact, the predictive value for different treatments, and the genetic heterogeneity of ROS1-positive patients. PATIENTS AND METHODS: 1137 patients w...

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Vydáno v:Oncotarget
Hlavní autoři: Scheffler, Matthias, Schultheis, Anne, Teixido, Cristina, Michels, Sebastian, Morales-Espinosa, Daniela, Viteri, Santiago, Hartmann, Wolfgang, Merkelbach-Bruse, Sabine, Fischer, Rieke, Schildhaus, Hans-Ulrich, Fassunke, Jana, Sebastian, Martin, Serke, Monika, Kaminsky, Britta, Randerath, Winfried, Gerigk, Ulrich, Ko, Yon-Dschun, Krüger, Stefan, Schnell, Roland, Rothe, Achim, Kropf-Sanchen, Cornelia, Heukamp, Lukas, Rosell, Rafael, Büttner, Reinhard, Wolf, Jürgen
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2015
Témata:
Clinical Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4496376/
https://ncbi.nlm.nih.gov/pubmed/25868855
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