Potentiating the cellular targeting and anti-tumor activity of Dp44mT via binding to human serum albumin: two saturable mechanisms of Dp44mT uptake by cells

Di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) demonstrates potent anti-cancer activity. We previously demonstrated that (14)C-Dp44mT enters and targets cells through a carrier/receptor-mediated uptake process. Despite structural similarity, 2-benzoylpyridine 4-ethyl-3-thiosemicarbazon...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Merlot, Angelica M., Sahni, Sumit, Lane, Darius J.R., Fordham, Ashleigh M., Pantarat, Namfon, Hibbs, David E., Richardson, Vera, Doddareddy, Munikumar R., Ong, Jennifer A., Huang, Michael L.H., Richardson, Des R., Kalinowski, Danuta S.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4496362/
https://ncbi.nlm.nih.gov/pubmed/25848850
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