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Urocortin3 mediates somatostatin-dependent negative feedback control of insulin secretion
The peptide hormone Urocortin3 (Ucn3) is abundantly expressed by mature beta cells, yet its physiological role is unknown. Here we demonstrate that Ucn3 is stored and co–released with insulin and potentiates glucose–stimulated somatostatin secretion via cognate receptor on delta cells. Further, we f...
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| 出版年: | Nat Med |
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| 主要な著者: | , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2015
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4496282/ https://ncbi.nlm.nih.gov/pubmed/26076035 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3872 |
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