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Urocortin3 mediates somatostatin-dependent negative feedback control of insulin secretion
The peptide hormone Urocortin3 (Ucn3) is abundantly expressed by mature beta cells, yet its physiological role is unknown. Here we demonstrate that Ucn3 is stored and co–released with insulin and potentiates glucose–stimulated somatostatin secretion via cognate receptor on delta cells. Further, we f...
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| Publicado no: | Nat Med |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4496282/ https://ncbi.nlm.nih.gov/pubmed/26076035 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3872 |
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