Synergistic inhibition of autophagy and neddylation pathways as a novel therapeutic approach for targeting liver cancer

Liver cancer is the second-most frequent cause of cancer death in the world and is highly treatment resistant. We reported previously that inhibition of neddylation pathway with specific NAE inhibitor MLN4924, suppressed the malignant phenotypes of liver cancer. However, during the process, MLN4924...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Chen, Ping, Hu, Tao, Liang, Yupei, Jiang, Yanan, Pan, Yongfu, Li, Chunjie, Zhang, Ping, Wei, Dongping, Li, Pei, Jeong, Lak Shin, Chu, Yiwei, Qi, Hui, Yang, Meng, Hoffman, Robert M., Dong, Ziming, Jia, Lijun
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2015
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4496198/
https://ncbi.nlm.nih.gov/pubmed/25797246
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