Celecoxib increases EGF signaling in colon tumor associated fibroblasts, modulating EGFR expression and degradation

We previously demonstrated that non-toxic doses of Celecoxib induced the immediate phosphorylation of Erk1-2 in colon tumor associated fibroblasts (TAFs), increasing their responsiveness to epidermal growth factor (EGF). We have now identified two concomitant mechanisms explaining the EGF-Celecoxib...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Venè, Roberta, Tosetti, Francesca, Minghelli, Simona, Poggi, Alessandro, Ferrari, Nicoletta, Benelli, Roberto
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2015
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4494940/
https://ncbi.nlm.nih.gov/pubmed/25987127
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