Zoledronate can induce colorectal cancer microenvironment expressing BTN3A1 to stimulate effector γδ T cells with antitumor activity

Amino-bis-phosphonates (N-BPs) such as zoledronate (Zol) have been used in anticancer clinical trials due to their ability to upregulate pyrophosphate accumulation promoting antitumor Vγ9Vδ2 T cells. The butyrophilin 3A (BTN3A, CD277) family, mainly the BTN3A1 isoform, has emerged as an important st...

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Vydáno v:Oncoimmunology
Hlavní autoři: Zocchi, Maria Raffaella, Costa, Delfina, Venè, Roberta, Tosetti, Francesca, Ferrari, Nicoletta, Minghelli, Simona, Benelli, Roberto, Scabini, Stefano, Romairone, Emanuele, Catellani, Silvia, Profumo, Aldo, Poggi, Alessandro
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2017
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5384426/
https://ncbi.nlm.nih.gov/pubmed/28405500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2016.1278099
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