Targeting the Epidermal Growth Factor Receptor Can Counteract the Inhibition of Natural Killer Cell Function Exerted by Colorectal Tumor-Associated Fibroblasts

Mesenchymal stromal cells (MSC) present in the tumor microenvironment [usually named tumor-associated fibroblasts (TAF)] can exert immunosuppressive effects on T and natural killer (NK) lymphocytes, favoring tumor immune escape. We have analyzed this mechanism in colorectal carcinoma (CRC) and found...

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Détails bibliographiques
Publié dans:Front Immunol
Auteurs principaux: Costa, Delfina, Venè, Roberta, Benelli, Roberto, Romairone, Emanuele, Scabini, Stefano, Catellani, Silvia, Rebesco, Barbara, Mastracci, Luca, Grillo, Federica, Minghelli, Simona, Loiacono, Fabrizio, Zocchi, Maria Raffaella, Poggi, Alessandro
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2018
Sujets:
Immunology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5992415/
https://ncbi.nlm.nih.gov/pubmed/29910806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.01150
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