Epidermal growth factor receptor mutation mediates cross-resistance to panitumumab and cetuximab in gastrointestinal cancer

Acquired resistance to epidermal growth factor receptor (EGFR) targeted antibodies represents a clinical challenge in the treatment of gastrointestinal tumors such as metastatic colorectal cancer, but its molecular mechanisms are incompletely understood. We scanned KRAS exon 2/3/4, NRAS exon 2/3/4 a...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Oncotarget
Main Authors: Braig, Friederike, März, Manuela, Schieferdecker, Aneta, Schulte, Alexander, Voigt, Mareike, Stein, Alexander, Grob, Tobias, Alawi, Malik, Indenbirken, Daniela, Kriegs, Malte, Engel, Erik, Vanhoefer, Udo, Grundhoff, Adam, Loges, Sonja, Riecken, Kristoffer, Fehse, Boris, Bokemeyer, Carsten, Binder, Mascha
Format: Artigo
Jezik:Inglês
Izdano: Impact Journals LLC 2015
Teme:
Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4494921/
https://ncbi.nlm.nih.gov/pubmed/26059438
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