RAB7 counteracts PI3K-driven macropinocytosis activated at early stages of melanoma development

Derailed endolysosomal trafficking is emerging as a widespread feature of aggressive neoplasms. However, the oncogenic signals that alter membrane homeostasis and their specific contribution to cancer progression remain unclear. Understanding the upstream drivers and downstream regulators of aberran...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Alonso-Curbelo, Direna, Osterloh, Lisa, Cañón, Estela, Calvo, Tonantzin G., Martínez-Herranz, Raúl, Karras, Panagiotis, Martínez, Sonia, Riveiro-Falkenbach, Erica, Romero, Pablo-Ortiz, Rodríguez-Peralto, José Luis, Pastor, Joaquín, Soengas, María S.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Priority Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4494909/
https://ncbi.nlm.nih.gov/pubmed/26008978
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