CSN6 deregulation impairs genome integrity in a COP1-dependent pathway

Understanding genome integrity and DNA damage response are critical to cancer treatment. In this study, we identify CSN6's biological function in regulating genome integrity. Constitutive photomorphogenic 1 (COP1), an E3 ubiquitin ligase regulated by CSN6, is downregulated by DNA damage, but th...

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Bibliografiske detaljer
Udgivet i:Oncotarget
Main Authors: Choi, Hyun Ho, Su, Chun-Hui, Fang, Lekun, Zhang, Jin, Yeung, Sai-Ching J., Lee, Mong-Hong
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2015
Fag:
Priority Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4494904/
https://ncbi.nlm.nih.gov/pubmed/25957415
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