HIF-1α and TAZ serve as reciprocal co-activators in human breast cancer cells

Hypoxia-inducible factor 1α (HIF-1α) expression is a hallmark of intratumoral hypoxia that is associated with breast cancer metastasis and patient mortality. Previously, we demonstrated that HIF-1 stimulates the expression and activity of TAZ, which is a transcriptional effector of the Hippo signali...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Xiang, Lisha, Gilkes, Daniele M., Hu, Hongxia, Luo, Weibo, Bullen, John W., Liang, Houjie, Semenza, Gregg L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2015
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Priority Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4494903/
https://ncbi.nlm.nih.gov/pubmed/26059435
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