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Structural impact of complete CpG methylation within target DNA on specific complex formation of the inducible transcription factor Egr-1
The inducible transcription factor Egr-1 binds specifically to 9-bp target sequences containing two CpG sites that can potentially be methylated at four cytosine bases. Although it appears that complete CpG methylation would make an unfavorable steric clash in the previous crystal structures of the...
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| 出版年: | FEBS Lett |
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| 主要な著者: | , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2015
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4494898/ https://ncbi.nlm.nih.gov/pubmed/25999311 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2015.05.022 |
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